CAS 458-37-7 High Quality Curcumin Extract Curcumin Powder

Details of CurcuminProduct Name:CurcuminAlias:Curcumin; 458-37-7; Diferuloylmethane; Natural yellow 3; Turmeric yellow; CurcumaCAS:458-37-7EINECS:207-280-5MF:C21H20O6MW:368.38Assay: 99%Melting point:183ºCWater solubility:Slightly soluble in waterDensity:0.93Appearance:Orange yellow crystalline powder
Descriptionof Curcumin
Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.Curcuminis a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmcologic properties.Curcuminblocks the formation of reactive-oxygenspecies, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. (NCI04).Curcuminis a natural component of the rhizome of turmeric (Curcuma longa) and one of the most powerful chemopreventive and anticancer agents. Its biological effects range from antioxidant, anti-inflammatory to inhibition of angiogenesis and is also shown to possess specific antitumoral activity. The molecular mechanism of its varied cellular effects has been studied in some details and it has been shown to have multiple targets and interacting macromolecules within the cell.Curcuminhas been shown to possess anti-angiogenic properties and the angioinhibitory effects ofcurcuminmanifest due to down regulation of proangiogenic genes such as VEGF and angiopoitin and a decrease in migration and invasion of endothelial cells. One of the important factors implicated in chemoresistance and induced chemosensitivity is NFkB andcurcuminhas been shown to down regulate NFkB and inhibit IKB kinase thereby suppressing proliferation and inducing apoptosis. Cell lines that are resistant to certain apoptotic inducers and radiation become susceptible to apoptosis when treated in conjunction withcurcumin. Besides this it can also act as a chemopreventive agent in cancers of colon, stomach and skin by suppressing colonic aberrant crypt foci formation and DNA adduct formation. This review focuses on the various aspects ofcurcuminas a potential drug for cancer treatment and its implications in a variety of biological and cellular processes vis-à-vis its mechanism of action (PMID:16712454). Turmeric (Zingiberaceae family) rhizomes, has been widely used for centuries in indigenous medicine for the treatment of a variety of inflammatory conditions and other diseases. Its medicinal properties have been attributed mainly to the curcuminoids and the main component present in the rhizome iscurcumin.Curcuminhas been shown to possess wide range of pharmacological activities including anti-inflammatory, anti-cancer, anti-oxidant, wound healing and anti-microbial effects. Recently,curcumintreatment has been shown to correct defects associated with cystic fibrosis in homozygous DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) knock out mice. In vivo and in vitro studies have demonstratedcurcumin's ability to inhibit carcinogenesis at three stages: tumor promotion, angiogenesis and tumor growth.Curcuminsuppresses mitogen-induced proliferation of blood mononuclear cells, inhibits neutrophil activation and mixed lymphocyte reaction and also inhibits both serum-induced and platelet derived growth factor (PDGF)-dependent mitogenesis of smooth muscle cells. It has also been reported to be a partial inhibitor of protein kinase. The other salient feature of turmeric/curcuminis that despite being consumed daily for centuries in Asian countries, it has not been shown to cause any toxicity (PMID:16413584).Usageof Curcumin
Curcumin is a natural phenolic compound.
Curcumin is a potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
Curcumin can induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity.
Reported to that Curcumin can inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages.
Curcumin is a potent inhibitor of EGFR tyrosine kinase and IκB kinase. Curcumin can inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase.
Curcumin easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Quality Specificationof CurcuminItems SpecificationsResultsMethodChemical Test compacted densityIdentificationPositive by HPLCBy IR spectrumThe IR spectrum of sample is concordant with that of standardSolubilitySlightly soluble in alcohol, soluble in acetone and in glacial acetic acidCompliesNoteAssayTotal Curcuminoids ≥95.0%95.1%HPLCE;1 (425nm)≥ 14501520UVLoss on Drying≤ 2.0%0.6%CP2010Ash≤ 1.0 %0.2%CP2010Compacted density0.5-0.9 g/ml0.63 g/mlCP2010Loose Bulk Density0.3-0.5 g/ml0.42g/mlCP2010Heavy metals≤ 10 ppmCompliesGB/T5009.74-2003Arsenic (As)≤ 2 ppm<0.3 ppmGB/T5009.11-2003Lead (Pb)≤ 2 ppm< 0.3ppmGB/T5009.12-2010Cadmium(Cd)≤1ppm0.2GB/T5009.15-2003Mercury (Hg)≤0.5ppm0.2GB/T5009.17-2003Solvent Residue--CompliesFDAMicrobial AnalysisTotal Plate Count< 10000 cfu/g3000GB4789.2-2010Yeast and Mold< 100 cfu/g50GB4789.15-2003Escherichia ColiNegativeNot DetectedGB4789.3-2010
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