99% Local Anesthetics Powder Procaine Hydrochloride Procaine HCl CAS 51-05-8

99% Local Anesthetics Powder Procaine Hydrochloride Procaine HCl CAS 51-05-8Product name: Procaine HCl
Alias: Procaine hydrochloride;Aminocaine;Anadolor;Atoxicocaine;Neocaine,Procaine hydrochlo,Procaine
CAS register number: 51-05-8
Molecular formula: C13H21ClN2O2
Molecular weight: 272.77
Melting point: 155-156 °C
Assay: 99%
EINECS: 200-077-2
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Appearance: White crystalline powder
Description:Procaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.White fine needle crystal or crystalline powder at room temperature, no smell, taste slightly bitter and Ma, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Procaine hydrochloride ester bond structure can be hydrolyzed to produce amino acid and diethylaminoethanol, under certain conditions, the amino acid may be further decarboxylated toxic aniline.The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ºC steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.The product structure of aromatic primary amino group in dilute hydrochloric acid can generate diazonium salt with sodium nitrite, coupling reaction occurs when add alkaline β-naphthol, generating azo compounds scarlet.Usage:Procaine hydrochloride is a kind of local anesthetics, for local anesthesia, nerve block etc, can block the conduction of nerve fibers with anesthetic effect, strong function, low toxicity, and no addiction, but the skin, mucous membrane penetration force is weak, not suitable for surface anesthesia, clinically used to infiltration, spine and conduction anesthesia.Side Effects:Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. about one in 3000 people have an atypical form of pseudocholinesterase,which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.
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