China 57-63-6 Ethynyl Estradiol Ethinylestradiol

Product DescriptionWhat is Ethynyl estradiol ?The phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferatCasting & Forging ion, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.

New product 99% Ethynyl estradiol 57-63-6

Ethynyl Estradiol is a synthetic analog of estradiol, often used in combination with a progestiElectronic Instrument n. Efficacy of administration isfacilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Rapidly absorbed fromgastrointestinal tract.

Certificate Of Analysis

Item

Specification

Results

Appearance

White to creamy white, odorless, crystalline powder.

white crystalline powder

Solubility

Car Safety

Insoluble in water; soluble in alcohol, in chloroform, in ether, in vegetable oils, and in solutions of fixed alkali hydroxides.

Conforms

Identification

A:IR B:UV

Conforms

SLifting Equipment pecific optical rotation

-28°~-29.5°

-28.3°

Melting range

180~186ºC

182.5~185.3ºC

Loss on drying

≤1.0%

0.45%

Residual Solvents

Acetone≤0.5%

0.08%

Assay

97.0~102.0% (on the dried basis)

99.43%

Particle Size

90% ≤10μ

Conforms

Conclusion

The product complies with specification in USP34

Medical uses:

Ethinyl estradiol(EE), also sometimes writtOscillator en asethinylestradiol,ethynyl

estradiol, orethinyl estradiol, is aderivativeof17 beta-estradiol(E2), the majorendogenousestrogenin humans. EE is an orallybioactiveestrogen used in manyformulationsofcombined oral contraceptive pills. It is one of the most

commonly usedmedicationsfor this purpose.

Transdermal ethinyl estradiol carries a greater risk of clot formation andvenous thromboembolismthan naturally occurring17-estradiol, which some have theorized

to be related to different amounts of hepatic metabolism after absorption. The samecontraindicationsand precautions apply for EE as with other estrogen medications.

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