China CAS: 624-49-7 Dimethyl Fumarate

Hot sale Dimethyl Fumarate CAS:624-49-7

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Product description:

Product name624-49-7CAS NO.C6H8O4BrandCrovellAppearanceWhite powderMFC6H8O4MW144.12532EINECS No.210-849-0Assay99%min

Product NameDimethyl fumarateSynonyms2(E)-Butenedioic acid 1,4-dimethyl ester; trans-butenedioicacid,dimethylester; trans-butenedioicaciddimethylester; Dimethyl
fumarate,99%; But-2-enedioicaciddimethylester;Fumaric acid, bis-methyl ester; Dimethyl fumaratedisc. 10/26/00; Dimethyl furmarateCAS624-49-7MFC6H8O4MW144.12532EINECS210-849-0Product CategoriesMiscellaneous Reagents; mildew preventive; Acids & Esters; C6 to C7; Carbonyl Compounds; EstersMol File624-49-7.mol

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Function
Dimethyl fumarate is the newest oral therapeutic for MS. While its mechanism is not completely understood, dimethyl fumarate
increases anti-inflammatory cytokines (IL-10, IL-4, and IL-6), decreases proinflammatory cytokines (IL-1β, IL-6, and TNF-α), and
activates the Nrf2 pathway to protect neuronal cells. Nrf2 is activated by covalent bond-forming electrophiles such as dimethyl
fumarate, a Michael acceptor.
Dimethyl fumarate has been used for the treatment of psoriasis in Europe since 1994 and has a favorable long-term safety profile.
An exploratory study in patients with relapsing remitting MS showed significant reductions in MS lesions after 18 weeks of
treatment with 720 mg/day of dimethyl fumarate. evaluation of dimethyl fumarate in a mouse experimental autoimmune
encephalomyelitis model of MS resulted in reduced spinal cord macrophage inflammation.Dimethyl fumarate is obtained in high purity
by esterification of fumaric acid with methanol and catalytic sulfuric acid.
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