China Ins 365 CAS211427-08-6 for Enhancement of Mucosal Hydration in The Treatment of Chronic Dry Eye

INS 365 CAS211427-08-6 for Enhancement of mucosal hydration in the treatment of chronic dry eye
1.Product detail

Product Name:INS 365Synonyms:INS 365;D03864;Diquafosol sodium;Diquafosol sodium (jan);Diquafosol tetrasodium;Diquafosol tetrasodium (usan);Diquafosol Impurity 7(UP4U);[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphateCAS:211427-08-6MF:C18H26N4O23P4·4Na

INS 365 Usage And Synthesis

DescriptionDiquafosol (INS-365) was approved in Japan in 2010 as a 3% ophthalmic solution for treatment of dry eye disease. Clinical diagnosis of dry eye is difficult because the condition presents a variety of symptoms. Treatment options include tear supplements (lubricants), anti-inflammatory drugs (e.g., cyclosporine eye drops or steroid eye drops), and tear retention devices. Diquafosol is a unique agent for the treatment of dry eye in that it acts as a P2Y2 purinergic receptor agonist with the ability to activate this receptor on the ocular surface and stimulate water, lipid, and mucin secretion. Diquafosol is metabolized by phosphodiesterases to UTP, UDP, UMP, and uridine. Diquafosol has been well tolerated in clinical trials, with side effects being local to the ocular surface.In addition,no serious ocular or systemic adverse drug reactions were found during the clinical trials.OriginatorInspire Pharmaceuticals (United States)UsesEnhancement of mucosal hydration in the treatment of chronic dry eye (P2Y2 receptor antagonist).

2. Packaging, transportation
3.Factory/laboratory

4.Company Information :
Hebei Xibaijie Biotechnology Co., Ltd dedicated to the development, production and marketing of chemicals which is specialized in pharmaceutical intermediates,Veterinary drug intermediates and Pesticide intermediates,our campany is located in Shijiazhuang,Hebei Province.For many years of hard working with high Developedtechnology, we are doing great jobs in China, and ranked in the top level of manufacturing medicine-used pharmaceutical intermediates. High purity of products, good price, short time of delivery, quick response of service. We are the manufacturer, we have better price, we have large stock for delivery in short time.After-sale Service : We will supply flexible service ways, various service ways such as common sample free, online service, global exhibitions and meeting face to face will be accepted. Clients' satisfaction is our principle. Good reputation is our origin! Let us reach a brilliant new achievement hand- in- hand!
5.Other popular products

6.Why choose us?
Our Concept
1. Client is first.We are trying to bring maximum profit to our clients and we only share small.

2. Credibility is the most important.

3. Quality control is our life. 4.Great sense of responsibility. We will be responsible for not only our products, our clients, our suppliers, also the society.

Our Advantage

1. Selecting raw materials strictly,our products are the highest purity.

2. Reasonable and competitive price. Provide the best and professional service.

3.Fast delivery of the samples ,samples from stock. Reliable shipping way.

3. Full experience of large numbers containers loading in Chinese sea port.

4. Best after-service after shipment .

5. Professional documents for your custom clearance.

Our Service

1. Tiely communication, reply within 12 hours. You can leave any messages or send email to us.

2. OEM/ODM Available.Trial order is available for testing after samples.

3. Free sample for your evaluation.Customers only need to undertake the shipping fee for deliver. It is relatively safe and fast.

4. The more discount you'll get if your order is potential.

5. Door to door shipping service is available.

6. Packing with pallet or as buyer's special request are all available.

1. Quality
Our products meet MSDS safe standard and we have ISO and other certificate so yan can get high quality products from our company.
2. Price
We are the company which is the joint of trade and industry so we cao provide the competitive price and high quality product.
3. Packing
We can do according to the customers' request.
4. Transport
The products can be transported by Courier, by air or by sea
5. Service
We offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand.

6.FAQ
Q1: Can i get small sample
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T .
Q3:What's your MOQ
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q4:How about the packing
A: Usually we provide the packing as 25kg/ bag/ carton/ drum. And we also can according to your requirment.
Q5: How about delivery leadtime
A:about 3-5 working days after receipt of your payment
Q6: How to contact us
A:You can chat with us by Trademanager&Skype Online.