Diclofenac Sodium Capsule

Diclofenac Sodium Sustained Release Capsules
Generic name: Diclofenac Sodium Sustained Release Capsules
Brand name: ANTINE
Composition: The chemical name is 2-[(2,6-dichlorophenyl) amino]benzene- acetic acid, monosodium salt.
Molecular weight:318.14.
Molecular formula:C14H10Cl2NNaO2
Chemical structure:Description:
The contents are white or white or yellowish spherical pellets
Strength:50mgIndications:
1)relieving acute-attack or persistent joint pain of various chronic arthritis such as rheumatoid arthritis, osteoarthritis, spondyloarthropathy, gouty arthritis, rheumatic arthritis, etc.;
2)various kinds of rheumatic pain for soft tissues, such as omodynia, tenosynovitis, bursitis muscle pain,damage pain after exercise, etc.;
3)acute mild and moderate pains, such as pain after operation, wound and strain , primary dysmenorrhea,toothache, headache, etc..
Dosage and administration:
Taken orally,and the Capsules must be swallowed whole and not chewed. 100mg (2 Capsules) once daily;or 50mg (1 Capsule) twice daily, or follow the doctor's advice.Precautions:
Gastro-intestinal disturbances such as nausea, vomiting, abdominal discomfort and diarrhoea may occur.
Peptic ulceration and gastro-intestinal bleeding have been reported. Other side-effects includenervousness,headache,dizziness,depression,drowsiness,insomnia, blurred vision andtinnitus.Oedema and skin reactions,such as rashes, urticaria, pruritus and eczema have been reported.
Abnormalities of liver function tests, impairment of renal functions, agranulocytosis, aplastic anaemia and thrombocytopenia have been observed. Sensitivity reactions such as bronchospasm or anaphylactoid reactions,jaundice, hepatitis, renal failure and nephrotic syndrome, may occur. Other side-effects that may occur areminor hearing disorders, irritability, agitation, palpitations,tiredness and increased serum transaminase levels.
PHARMACOLOGICAL ACTION:
ANTINE is a non-steroidal compound with antirheumatic, anti-inflammatory, analgesic and antipyretic action.
In vitro its active substance strongly inhibits prostaglandin synthetase and also has an inhibitory effect on
platelet aggregation. Veltex inhibits prostaglandin biosynthesis and this inhibition has an important bearing on
its mechanism of action. Prostaglandins appear to play a major role in causing inflammation, pain and fever.
ABSORPTION:
The micro-pellets contained in the ANTINE CAPSULES will be released in the stomach and mixed with its
contents reaches the intestinal tract, where dissolution occurs slowly. Serum peak levels are achieved within
1to 3hours and due to the quantity of diclofenac presented in these micro-pellets an extended plasma
concentration is maintained.
Storage:Protect from light, and keep air-tightly.
Packs:10Tablet/Blist/Box
Shelf-life:24 months