High Quality Raw Material Granisetron Hydrochloride CAS 107007-99-8

Product Description
1. CAS No.: 107007-99-8
2. Quality: EP7/USP current
3.Character:White crystalline powder
4. document: GMP/ISO
Granisetron is aserotonin 5HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is anerve that activates the vomiting center in the medulla oblongata. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.
Items
Specifications
Results
Appearance
White or almost white powder
Conforms
Identification
A: IR Spectrum
A: Sample IR spectrum comparable with that of the standard
Conforms
B: Chloride
B: Positive
Conforms
pH
4.0~6.5
5.92
Impurity E(by TLC)
NMT0.5%
<0.5%
Loss on drying
NMT0.5%
0.03%
Heavy metals
NMT20ppm
<20ppm
Related Compounds
Impurity A: NMT1.0%
ND
Impurity B: NMT0.5%
ND
Impurity C: NMT0.2%
0.04%
Impurity D: NMT0.1%
ND
Any other impurity :NMT1.0%
0.03%
Total impurity: NMT1.0%
0.07%
Residual Solvents
Ethanol
NMT 1000ppm
314ppm
NMT 1000ppm
13ppm
NMT 300ppm
2ppm
Assay by HPLC
97.0%~102.0%
100.10%
Conclusion
The product meets USP SpecificationsPacking
WeightPackage<25KG
By foil-alum bag/pap/bottle≥25kgPackage: 25kg/drum/bag or as your request
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