Local Anesthetic Procainamide Hydrochloride 13754-56-8 Procainamide HCl

Local anesthetic Procainamide Hydrochloride 13754-56-8 Procainamide HClProcainamide HCl Basic info:CAS No: 614-39-1
Synonyms :Amide, Procaine Hydrochloride, Procainamide Hydrochloride ; Novocainamide Apo-Procainamide Hydrochloride ;Rhythmin ; Procanbid Hydrochloride ; Novocainamide Hydrochloride ; Novocamid Hydrochloride ; Procainamide HCl Procanbid
Molecular weight: 271.79
Molecular formula: C13H21N3O.HCl
Assay: 99%
EINECS: 200-077-2
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Appearance: White crystalline powder
Storage instructions:Store at +4°C.
Delivery terms:HKEMS,DHL,TNT,EMS,Fedex,UPS
Payment:Western Union, Money gram, T/T,BitcoinCOA:

Items

Specifications

Results

Appearance

A white or almost white crystalline

A white powder

Identification

A,B,C in Pass

Complies

Melting Point

173 - 178 ºC

174-177.5ºC

Acidity(PH)

4.0 - 7.0

6.6

Loss on drying

≤ 1.0 %

0.33 %

Residue on ignition

≤ 0.2 %

0.034%

Assay

98 - 102 %

99.72%

CONCLUSION

Pass USP 34

Usage:
Procaine hydrochloride is a kind of local anesthetics, for local anesthesia, nerve block etc, can block the conduction of nerve fibers with anesthetic effect, strong function, low toxicity, and no addiction, but the skin, mucous membrane penetration force is weak, not suitable for surface anesthesia, clinically used to infiltration, spine and conduction anesthesia.Description:
Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.
Procaine HCL is actually a very simple combination of two B vitamins, PAPA (P-aminobenzoic acid) and DEAE (diethylaminoethanol) buffered and stabilized with benzoic acid and potassium metabisulfite for more effectiveness inside the body. Procaine hydrochloride is a compound combination of PABA and DEAE, a vitaminic substance first synthesized in 1905 by a German chemist, Dr. Albert Einhorn, who was looking for a simple, non-addictive anesthetic.
Procine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine HCl (procaine hydrochloride) is the active ingredient in Gerovital H3(GH3) and in the Vitacels 3 through 8. Procaine HCl is broken down rapidly by enzymes in the blood stream into PABA and DEAE. The PABA and DEAE are rapidly conjugated and removed from the blood and excreted from the body. Because of this procaine HCl and its breakdown products (metabolites) are unable to get into the cells in any great quantity to produce benefits. Procaine HC will produce some benefits by itself, but they are very limited.Applications :
Procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.
Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. about one in 3000 people have an atypical form of pseudocholinesterase, which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.
Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.Related Products Lists:ProductName CAS NumberBupivacaine Hydrochloride 14252-80-3Bupivacaine 2180-92-9Dibucaine Hydrochloride 61-12-1Ropivacaine Hydrochloride 132112-35-7Levobupivacaine Hydrochloride 27262-48-2Articaine Hydrochloride 23964-57-0Linocaine Hydrochloride 6108-05-0Benzocaine 94-09-7Benzocaine Hydrochloride 23239-88-5Procaine Hydrochloride 51-05-8Proparacaine Hydrochloride 5875-06-9Propitocaine Hydrochloride 1786-81-8Xylocaine 137-58-6Tetracaine 94-24-6Tetracaine Hydrochloride 136-47-0DibucaineHydrochloride 61-12-1Prilocaine 721-50-6Procaine Penicillin G 54-35-3Sodium 2-Hydroxybutyrate 5094-24-6Tetracaine Hydrochloride 136-47-0Pramoxine Hydrochloride 637-58-11-PHENETHYL-N-PHENYLPIPERIDIN-4-AMINE 21409-26-7