Local Anesthetic Tetracaine Hydrochloride / Tetracaine HCl 136-47-0

Local Anesthetic Tetracaine hydrochloride / Tetracaine HCl 136-47-0Tetracaine HCl Basic info:
Product Name
Tetracaine hydrochloride/ Tetracaine HCl
CAS
136-47-0
MF
C15H25ClN2O2
MW
300.82
EINECS
205-248-5
Categories
API intermediates;Sodium channel;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;PONTOCAINE;Local anesthetic
Appearance
Pure White Crystalline Powder
Assay
99.8%min
MP
149°C
Standard
USP/BP
Package
Aluminum foil bag inside+ Carton box outside;1kg/bag,25kg/drum/ or discreetly disguised packings
CAS: 136-47-0
Product Name: Tetracaine hydrochloride
Synonyms: INTERCAIN HYDROCHLORIDE
MF: C15H25ClN2O2
MW: 300.82
EINECS: 205-248-5
mp: 149°C
storage temp: Refrigerator
Appearance: White Solid
Delivery terms:HKEMS,DHL,TNT,EMS,Fedex,UPS
Payment:Western Union, Money gram, T/T,BitcoinCOA:
Test Items
Specification
Test Results
Appearance
Fine, white, crystalline, odorless powder
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Identification
ABC in Pass
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Solubility
Very soluble in water, soluble in Alcohol; insoluble
in Ether and Benzene
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USP Reference standards
USP Tetracaine Hydrochloride RS. USP Endotoxin RS.
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Melting point
145~150 degree
146.0~147.5
degree
Chromatographic purity
In Pass
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Related substance
Not more than the reference solution 0.05%
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Heavy metals
≤10ppm
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PH
4.5-6.5
5.8
Residue on ignition
≤0.10%
0.05%
Loss on Drying
≤ 0.5%
0.19%
Assay
98.0 -101.0%
100.1%
Conclusion
Confirms USP 32
Description:Tetracaine (also known as amethocaine) is a local anesthetic of the ester anesthetic group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine hydrochloride used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.
A systematic review investigated tetracaine for use in emergency departments, especially for intravenous cannulation in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first-attempt cannulations.Application:
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent
local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and
it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine
receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker
of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium
release events, while at high concentrations, tetracaine blocks release completely.
Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5 (per myriad), a half per mille (0.5‰),
or .05 per cent (1 part in 2000) adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose
& throat surgery and in the emergemcy department where numbing of the surface is needed rapidly,
especially when children have been injured in the eye, ear, or other sensitive locations.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication
needed in a basic health system. A systematic review and meta-analysis of randomised controlled trials
investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view
of its analgesic and cost-saving properties however it did not find a statistically significant improvement in
first attempt cannulations.
Used for mucosal epidermal anesthesia, nerve tissue anesthesia, epidural anesthesia and Subarachnoid space anesthesia.
In the manufacture of pharmaceutical preparation for external use, to relieve the pain of drugs or medication lesions pain.
-6, Function of Lidocaine Hydrochloride:
A- For block anesthesia and epidural anesthesia.
B- Also used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
C- As painkillers of injection in the medicament.
D- Also used in suppository and ointment preparation, etc.
-7, Function of Benzocaine: For cosmetics ultraviolet absorption, local anesthetics, for wounds, ulcers and hemorrhoids pain.
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