Medical Anhydrous Glucose Production Line

Medical anhydrousGlucose Prodution Line
Processes
1.1. Preparation for {0><}0{>starch milk: Refinedstarchfromplantstarch was dissolvedintothewatertankto be adjusted to 19to 20Be, then adding Na2CO3 to adjust the PH to 5.4to 6.0, and addingαamylase to be ready for liquefaction.1.2. {0><}0{>Liquefaction<0}:{0>,,,110oC,30,0.2MPa,,98oC,20,,.<}0{>Put the starch milk prepared to the 1st injector and inject steam directly to the starch milk. Make the temperature rise to 110ºCquickly. After entering the 1st flash evaporator, lower the temperature to 98ºCand keep it for a certaintime. The material, after initial hydrolysis, is with a lower viscidity. <0}{0>,135oC,10,95oC,2/3α-,90~120,DE12~18.<}0{>The material is then put into the 2nd injector by the pump, its temperature reaching 135ºCquickly, then it gets to the 2nd flash evaporator. The temperature in the 2nd flash evaporator declines to 95ºC. The DE volume of the material would be between 15 and 20 after its staying in the tubular reactor for 90-120 minutes.
1.3. Saccharification<0}: Puthydrochloric acidinto the material after liquefaction and make the PH volume to 4.0to 4.5, while lowering the temperature from 90ºCto 60ºC. Add fungal enzymes and glucoamylaseinto it and keep stirring at that temperature. DE valuewill be 95after the saccharificationperiod will take 48 to 54 hours.
1.4. Refining<0}:After refining, impurities, protein, fat, pigment, and edible salt are removed from the saccharification liquid. The material should now first be put into the Board frame filter. The best temperature for filtration is 70ºCto 85ºC. The insoluble protein and fat is separated and the clear andslightly colored saccharification liquid comes into being. The next section is charcoal absorptionwhich further separates the insoluble protein and pigment. Keep adding inactive carbon at the temperature between 75ºCand 85ºCin order to make the material have enough contact with active carbon. Then put the material into filter to separate carbon from it. Another round of check and filtration is needed to make sure there is no more carbon.
1.5. {0><}0{>Ion exchange<0}:After filtration, amino acid and Inorganic salts are separated from the saccharification liquid. The temperature of the material should be lowered to 48to 50ºCto take ion exchange, firstly cation exchange column resin, and secondly anion-exchange column resin. During cation exchange column, Na, Fe, Ca, Cu and a part of amino acid are separated, and during anion-exchange column, chloride, sulfate, phosphate, and most of the soluble amino acid can be taken off, which makes the refined saccharification liquid come into being.
1.6.Concentration: After purificationDS of liquid glucoseisabout 30%, the liquid glucoseis into thefalling filmevaporatorto concentrate after adjusting the PHvalue, the concentration of concentratedglucoseis 70to 75%.
1.7. Crystallization: The concentratedglucosesolutionwas cooled to45 ºCand was pumped intothe crystallizerof glucose. Thecrystallizer is a specialequipment, the crystallization process is automatic control, materialin the crystallizerslowlydropped to26 ºC,the material is discharged after 60 hours ofcontinuous crystallization.1.8. Separation: After crystallizationmassecuiteis centrifugedand the crystals is separatedfrom themother liquor, theseparationmachine is automatic speed. To ensure thepurity of the crystals, it is washed twicewithpure water.
1.9. Dissolveglucose:The crystals fromthe centrifugeis transported todissolvetank by the screw conveyor, thesecondmother liquorand purified water(RO water) is mixed, the quantityof mother liquorand purified wateris added in tankis adjusted automatically by thematerial density.
1.10. Bleachingfilter: The purposeof the seconddecolorization is to remove colored substances, and further reducepyrogensand increasingfiltration rate of material.
Material is into thebleaching tank, charcoal machinewith acontinuous quantitativeoutputaddedpowdered activated carbon in tank, bleachingtimeis 30 minutes, thenwithframe filterforfirst filtering andcheck the filter, to ensurethe quality ofthe filtrate, the filtrate passes throughtwoprecision filter.1.11. Boiling glucoseand Crystallization: After fine filtration, the materials were separately put into the storage tank before boiling glucose, and crystallized in twovacuum boiling glucosecans. First, about 1/3 of the volume of material is added to the glucosetank. At a certain vacuum and temperature, it is concentrated to the starting point. A certain amount of seed is added to control the supersaturation, so that the crystal growth can be controlled. The refined filtered glucose syrup is automatically added in a certain proportion, so that the crystal production can maintain a certain concentration. When it reaches the full liquid level, it stops feeding. After the final boiling of glucose, the glucosepaste is put into the feeding tank of the centrifuge.
1.12. Second separation: Massecuitefrompanscontainingincludes anhydrous glucosecrystalsandmother liquor, it is separated bytwosetsbasketcentrifuge. Mother liquorandwash wateris collected ina buffer tank,
anhydrous glucosecrystalsis fed thecorrespondingdrying andpackaging processes.
3-13.Drying, package: Themoisture of materialfrom the centrifuge is about 3%, it is reach at ≤0.8% after drying..