Pharmaceuticals CAS 78246-49-8 Treat Depression Paroxetine HCl/Citalopram Hydrobromide CAS 59729-32-

Product DescriptionBasic information of Paroxetine hcl
Prouduct name:Paroxetine HCL
CAS: 78246-49-8
Appearance: White Powder
Grade: 99.0%minIntroduction of Paroxetine hcl
Paroxetine, also known by the trade names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of hot flashes and night sweats associated with menopause.
It has asimilar tolerability profile to other SSRIs. The common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping and delayed ejaculation. It may also be associated with aslightly increased risk of birth defects.The incidence of withdrawal symptoms is higher withparoxetineand venlafaxine.Several studies have associatedparoxetinewith suicidal thinking and behavior in children and adolescents
Function&ApplicationFunction of Paroxetine hcl
Paroxetineis primarily used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, social anxiety disorder, panic disorder, generalized anxiety disorder, premenstrual dysphoric disorder and menopausal hot flashes.COA
ItemSpecificationResultAppearanceA White or almost white crystalline powderConformsIdentificationIRHPLCChloride testWaterConformsPH5.5 -7.56.4Sulphate ash≤0.1 %0.05%Heavy metal≤20 ppm< 20 ppmImpurity D≤0.2%Not DetectedImpurity G≤ 1ppm< 1ppmRelated substanceImpurity A≤0.3%Any other impurity ≤0.1%Total impurity ≤0.5%0.06%0.05%0.06%Residue solventsAcetone ≤0.5%0.05%Methanol ≤0.3%< 0.03%Isopropanol ≤0.5%0.05%Toluene ≤0.089%< 0.08%Assay97.5~102.0%99.5 %ConclusionThis product complied with the standard of EP 7.0High quality USP 39/EP 9.0 /BP 2012 Citalopram Hydrobromide CAS NO 59729-32-7
Name:Citalopram
CAS:59729-32-7
MF:C20H22BrFN2O
MW:405.3
Assay: 98%min
appearance:White or almost white powder, slightly soluble in water, soluble in Ethanol.
Citalopramis ramification of Phthalane, anew antidepressant, which has most opposite-selectivity to inhibiting resorption for 5-hydroxytryptamine (5-HT) in congener drugs. Citalopram HBr can inhibit resorption of 5-HT effectively, and is slight to resorption of dopamine and noradrenalin, and is weak or almost none to appetency of alkali-toadstool, histamine and 5-HT acceptor.
COA
ItemStandardTest Results
Identification
A.H-NMR:Comply with the structure
Complies
B.LC-MS:Comply with the structure
Complies
C.The IR spectrum of sample should be identical with that of reference standard;
Complies
D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
Complies
Crystallinity
meets the requirements.
Complies
Loss on drying
≤2.0%
0.19%
Heavy metals
≤10 ppm
<10ppm
Water
≤1.0%
0.1%
Sulphated ash
≤0.5%, determined on 1.0 g.
0.009%
Related substances
Unspecified impurities: for each impurity
≤0.10%
<0.10%
Total Impurity
≤0.5%
0.18%
Purity
≥99.0%
99.7%
Assay
99.0%~101.0% (anhydrous substance).
99.8%
Microbiological Analysis
Total plate count
≤1000cfu/g
Complies
Yeast and Moulds
≤100cfu/g
Complies
E. Coli.
Absent
Negative
Salmonella
Absent
Negative
S.aureus
Absent
Negative
Storage
Preserve in well-closed, light-resistant and airtight containers.
Complies
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