Zx NMP CAS 872-50-4 N-Methyl Pyrrolidone

ZX NMP Basic informationOutlineReference quality indicatorsUsesChemical PropertiesProduction methodsCategoryToxicity gradingAcute toxicityIrritation dataFlammability hazard characteristicsStorage featureExtinguishing agentsProfessional standardsProduct Name:ZX NMPSynonyms:M-PYROL(R);N-METHYLPYROLIDONE;N-METHYLPYRROLID-2-ONE;N-METHYLPYRROLIDINONE;N-METHYLPYRROLIDNONE;N-METHYLPYRROLIDONE;NMP-T;NMP-ELCAS:872-50-4MF:C5H9NOMW:99.13EINECS:212-828-1Mol File:872-50-4.molZX NMP Chemical PropertiesMelting point−24°C(lit.)Boiling point202°C(lit.)density1.028g/mLat 25°C(lit.)vapor density3.4 (vs air)vapor pressure0.29 mm Hg ( 20 °C)refractive index20/D1.479Fp187°Fstorage temp.2-8°Ccolor≤20(APHA)Water Solubility>=10 g/100 mL at 20 ºCSensitiveHygroscopicMerck14,6117BRN106420Stability:Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases.CAS Database Reference872-50-4(CAS Database Reference)NIST Chemistry Reference2-Pyrrolidinone, 1-methyl-(872-50-4)EPA Substance Registry System2-Pyrrolidinone, 1-methyl-(872-50-4)Safety InformationHazard CodesT,XiRisk Statements45-65-36/38-36/37/38-61-10-46Safety Statements41-45-53-62-26WGK Germany1RTECSUY5790000F3-8-10TSCAYHazardous Substances Data872-50-4(Hazardous Substances Data)ZX NMP Usage And SynthesisOutline1-Methyl-2-pyrrolidinone is abbreviated as NMP. Molecular formula: C5H9NO.Appearance is colorless to transparently pale yellow liquid, which is slight odor of ammonia, and can be miscible with water in any proportion, soluble in ether, acetone and esters, halogenated hydrocarbons, aromatic hydrocarbons and other organic solvents. It can be mixed with almost all the solvent, boiling point:204 ºC, flash point:91 ºC, moisture absorption strongly, chemical property stability, non-corrosive to carbon steel and aluminum, slightly corrosive to copper. Its advantages: Low viscosity, good chemical stability and thermal stability, high polarity, low volatility, miscible infinitely with water and many organic solvents. This product is a micro-drug. Allowable limit concentration is 100PPM in the air.Reference quality indicatorsTesting items Target
Appearance colorless transparent liquid (above 25 ºC)
Purity% ≥99.5
Moisture% ≤0.1
Chroma HaZen≤25
Refractive index N20D 1.468-1.471
Density 1.032-1.035Uses1-Methyl-2-pyrrolidinone is a polar aprotic transfer solvent. It has little toxicity, high boiling point, outstanding solvency, high selectivity and good stability. It is Widely used in purification of aromatics extraction, acetylene, olefin, diolefin, as solvent of polyvinylidene fluoride, lithium ion secondary battery electrode materials, in the synthesis gas desulfurization, refining lubricating oil, as lubricating antifreeze agent, an olefin extractant, solvent for polymerization of indissolvable plastic, agricultural herbicides, insulation materials, production of integrated circuits, precision instruments of semiconductor industry, in cleaning circuit boards, recycling the exhaust gas of PVC, cleaning agents, as dyes additives, dispersing agents, etc. It is also used as solvent for the polymer and medium for polymerization reactions, such as engineering plastics and aramid fibers. It may also be used in pesticides, pharmaceuticals and cleaning agent, etc.
1-Methyl-2-pyrrolidinone is an excellent extraction solvent, widely used as extracting agent for aromatic extraction, acetylene concentration, separation of butadiene and synthetic gas desulfurization process, etc, also as the solvent of pesticides, plastics, paints, production of synthetic, integrated circuits, etc. It can also be used for industrial detergents, dispersants, coloring agents, lubricants, antifreeze agent, etc. The product is low toxic and the rat oral LD50 is 7ml/kg.
The above information is edited by the chemicalbook of Yan Yanyong.Chemical PropertiesIt is transparently colorless oily liquid, slight odor of amine . It can be miscible with water, alcohols, ethers, esters, ketones, halogenated hydrocarbons, aromatics.Production methodsIt is produced by the reaction of γ-butyrolactone with methylamine. The first step is that methylamine reacts with γ-butyrolactone to produce 4-hydroxy-N-methylbutanamide, and then the second step is further dehydration to produce 1-Methyl-2-pyrrolidinone. Two-step reaction can be conducted in a tubular reactor continuously, and the molar ratio of γ-butyrolactone to methylamine is 1: 1.15, pressure is about 6MPa and temperature is 250 ºC. After completion of the reaction, and then by concentration and vacuum distillation, product is derived. Yield is 90%. If the production is conducted in tank reactor, Dosage of methylamine is 1.5 to 2.5 times of the theoretical amount. For laboratory preparation, for example, 2 mols of γ-butyrolactone and 4 moles of liquid methylamine were added In 500ml autoclave vessel, heat sealed and held at 280 ºC for 4h. After cooling, the release of excess methylamine, distillation, collecting 201-202 ºC fraction, the product was about 180g, the yield of which was approximately 90%. Raw material consumption (kg/g) forγ-butyrolactone and methylamine (40%) were 980 and 860.CategoryFlammable liquidToxicity gradingpoisoningAcute toxicityoral-rat LD50: 3914 mg/kg, Oral-Mouse LD50: 5130 mg/kgIrritation dataEye-rabbit moderate 100 mgFlammability hazard characteristicsIn case of fire, high temperature, strong oxidants, it is combustible. It is thermally decomposed to produce toxic nitric oxide gas.Storage featurecomplete package, wrapped and laid carefully, warehouse ventilation, away from open flame, heat, and stored separately from oxidantsExtinguishing agentsFoam, carbon dioxide, dry power, sandy soilChemical Propertiescolourless or light yellow liquid with an amine odourUsagehigh purity grade for ICP-MS detectionUsageIt is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.DefinitionChEBI: A member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.Professional standardsTWA 100 PPM (400 mg/cubic meter), STEL 100 mg/cubic meterGeneral DescriptionA clear colorless liquid with a "fishlike" odor. Denser than water. Flash point 199°F. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion.Air & Water ReactionsSoluble in water.Reactivity ProfileThis amine is a very mild chemical base. 1-Methyl-2-pyrrolidinone does tend to neutralize acids to form salts plus water. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.Health HazardInhalation of hot vapors can irritate nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes causes irritation. Repeated and prolonged skin contact produces a mild, transient irritation.Fire HazardSpecial Hazards of Combustion Products: Toxic oxides of nitrogen may be formed in fire.