China Bp Ondansetron HCl with Antemetic

CAS NO:146475-23-2/146844-89-5
MF: C17H19F2N3O3
Standard: BP/EP/USP
ASSAY: 98~102%
Appearance:White or almost white crystalline powder.Slightly soluble in water, very slightly soluble in methanol, practically insoluble in ethano

Product Nameondansetron HCLDescriptionWhite or almost white crystalline powderSolubilitSlightly soluble in water, very slightly soluble in methanol, practically insoluble in ethanoIdentificatio IR vs standardTest for specific optical rotationAppearance of solutionThe solution is clear and colorlessAcidity Not more than 0.6ml of 0.01M Naoh is required to change the color of the indicator to pinkSpecific optical rotatio+74.5°~ +78.0°Related SubstancesImpurity A≤0.1%Impurity B≤0.1%Any other impurity≤0.1%Total of other impurities≤0.1%Total of impurities≤0.3%Impurity D≤0.1%Silver≤5ppmLoss on drying≤0.5%Assay 98~102% (dried substance)Bacterial endotoxins<1.0iu/mg

ondansetron hcl is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic, often following chemotherapy. It affects both peripheral and central nerves. ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone. It has little effect on vomiting caused by motion sickness, and does not have any effect on dopamine receptors or muscarinic receptors.

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