China Pure 99% Prostaglandin E1 CAS 745-65-3 Alprostadil Pge 1 Powder

pure 99% PROSTAGLANDIN E1 CAS 745-65-3 Alprostadil PGE1 PGE 1 powder

Physical Characters and specifications

Product nameProstaglandin E1CAS No.745-65-3Other NamesPGE1Molecular FormulaC20H33O5Molecular weight354.48EINECS NO.212-017-2Grade StandardMedicine GradeCOAPlease contact with Senwayer freely

ItemSpecifications AppearanceWhite or almost white crystalline powder.Purity99%minMelting point115-116ºCSpecific rotation-64 º (c=1.0, C2H5OH)Boiling point407.69ºCDensity1.0458Refractive index1.6120Acidity coefficient (pKa)pKa 4.85± 0.07(H2O,t=25±0.1,I=0.1(NaCl)) (Uncertain)Solubilityethanol: 1 mg/mLStorage condition-20ºCShelf life2 years

Alprostadil, USP for intravascular infusion contains 500 micrograms Alprostadil, more commonly known as prostaglandin E1, in 1 mL dehydrated alcohol.

The chemical name for Alprostadil is (1R,2R,3R)-3-Hydroxy-2-[(E)-(3S)-3-hydroxy-1-octenyl]-5-oxocyclopentane heptanoic acid, and the molecular weight is 354.49.

Alprostadil is a white to off-white crystalline powder with a melting point between 110° and 116° C. Its solubility at 35° C is 8000 micrograms per 100 mL double distilled water.

Alprostadil (Prostglandin E1) is used to treat erectile dysfunction (ED) in adult males. The efficacy of alprostadil in treating ED varies with the cause; response rate is generally lower in patients with ED due to mixed etiologies compared to those with ED due to neurogenic, psychogenic, or vasculogenic causes. Additionally, PGE1 has been shown to affect protein kinase C (PKC), calcium movement, and adenylate cyclase yielding a multitude of physiological effects.
Prostaglandin E1 will prevent the ductus arteriosus from closing and reestablish ductal patency if closure has already occurred, and thereby increase PaO2, and mitigate the onset of metabolic acidosis. This drug is indicated for the temporary management of the neonate with ductus-dependent congenital heart disease while awaiting transfer to a tertiary care nursery for evaluation and surgical therapy. It is also used to stabilize a neonate's condition until surgery can be completed.