USA Warehouse High Purity, Factory Supply Free Samples manufacturer / supplier in China, offering Whitening & Freckle Removing Series Cosmetic Peptide Decapeptide-12 CAS. 137665-91-9, Factory Supply High Quality Wholesale Price Synephrine HCl 99% Purity CAS 5985-28-4, Factory Supply Wholesale Price High Quality Higenamine HCl 99% Purity CAS 11041-94-4 and so on.
Min. Order / Reference FOB Price | |
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100 gram | US $10.00/ gram |
Local Area: | Hubei, China |
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R&D Capacity: | OEM, ODM, Other |
Payment Terms: | LC, T/T, PayPal |
Powder: | Yes |
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Customized: | Non-Customized |
Certification: | GMP, HSE, ISO 9001, USP, BP |
Products Name: Fluoxetine hydrochloride
Synonyms : Methyl[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amine hydrochloride; N-Methyl-gama-[4-(trifluoromethyl)
CAS No: 59333-67-4;56296-78-7
EINECS No: 260-101-2
Molecular Formula: C23H23NO4
Molecular Weight: 377.433
DescriptionFluoxetine was shown to be effective for depression in six-week-long double-blind controlled trials, where it also alleviated anxiety and improved sleep. Fluoxetine was better than placebo for the prevention of depression recurrence when the patients, who originally responded to fluoxetine, were treated for a further 38 weeks. Efficacy of fluoxetine for geriatric, as well as pediatric, depression was also demonstrated in placebo-controlled trials.
Research suggests that a significant part of the resistance to the SSRIs paroxetine (Paxil) and citalopram(Celexa) can be explained by the genetic variation of Pgp transporter. Paroxetine and citalopram, which are Pgp substrates, are actively transported from the brain by this protein. Fluoxetine is not a substrate of Pgp, and thus a switch from paroxetine or citalopram to fluoxetine may be beneficial to the nonresponders
Appearance
White crystal
White crystal
Identification
A:Infrared absorption
B:Retention of time
A: Positive
B: Positive
A: Complies
B: Complies
Assay
98.0~101.5%
100.20%
Optical rotation
-0.05~+0.05
+0.01
Total impurity
≤0.5%
Complies%
3-methylaminol-l-phenylpropan-l-ol
≤0.25%
0.05%
N-methyl-3-phenylpropyl-l-amine
≤0.25%
0.05%
N-methyl-3-phenyl-3-(trifluoromet hylphenoxy)propyl-l-amine
≤0.15%
0.03%
Other impurity
≤0.10%
Complies
Organic volatile impurity
Complies
Complies
Sulphated ash
≤0.1%
0.02%
Water
≤0.5%
0.20%
pH
4.5~6.5
5.70
Heavy metals
≤10ppm
Complies
Solubility
Colorless clear
Colorless clear
TVC
≤10 cfn/g
Complies
Mould and yeast
≤10 cfn/g
Complies
Conclusion: comply with the USP30/BP2002